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Why does Aceyl-CoA not travel via the bloodstream (As is not as a ketyone etc.)?

Update:

Acetyl- CoA is an enzyme... not a fat...its functions in the oxidization and synthesis of fats but it itself is not... it also has a hydroxyl (OH) and a phosphoryl (with an o- ) group which i would assume make it not hydrophibic...

Update 2:

free fatty acids also are able to bind to serum albumin so that they can be transported in the blood stream

_ im leaning to wrads the regulation of the levels of Acetyl-CoA across the cytosol and mitochondrial matrix has having something to do with it... also maybe the reactivity of the Acetyl-CoA would make it impossible to reach the target tissue... a ketone would be unreactive until it reaches the cell, is transported across and then turned back to Aceytl-CoA

Update 3:

Within the liver Acetyl-CoA is converted into Ketones so to allow Beta-oxidation to continue (frees up coenzymeA) , these ketones then travel to target tissue where they are then transported into the cell and changed back into Acetyl-CoA to be used in the oxidation cycle... The question im trying to answer is why they need to be convert to Ketones in order to travel via the blood stream to these cells and so therefore why is Acetyl-CoA not transported in the blood as Acetyl-CoA

Update 4:

AHHHA !!! I just answered my own darn question.... the WHOLE point of making Keytones is to free up the coenzyme A, allowing oxidization in the liver to continue.... IF the Acetyl-CoA where to be transported via blood stream it would take that Coenzyme A with it... hahahahah YAY found it ;) Thanks for the help :) really did help by explaining it lol :)

Update 5:

ANNNDDD since all cells maintian highly regulated compartimalized sections of coenzyme-A it would make it very difficult to regulate with constant blood transporting ... hmm im putting that down too lol

1 Answer

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  • Lozza
    Lv 7
    10 years ago
    Favorite Answer

    It is insoluble (as it is a fat), so won't dissolve into the watery substances that make up the blood (plasma), so cannot be transported into the blood, as it needs things to be water soluble, before transportation.

    EDIT: Pardon me, I do apologise. Too much on the brain lol. You may have something there. But then it wouldn't need to travel via the blood stream if its made in the cell, because it would be used by the cell's mitochondria either way, right? And if there is excess, would it not be converted to...citrate to be exported from the mitochondria?

    EDIT 2: Haha, congratulations! Glad I could sort of help lol! :)

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